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KMID : 0363319980190020381
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Journal of Korean Oriental Internal Medicine
1998 Volume.19 No. 2 p.381 ~ p.391
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Effects of Bombusae concretio Salicea on amyloid-β-induced Neuronal Cell Toxicity and Lipid Peroxidation in Cultured Rat Astrocytes
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Lee Woo-Heon
Jung Ji-Chun
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Abstract
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The present study was done to investigate the effects of Bombusae concretio Salicea (BCS) on cultured astrocyte cell system and lipid peroxidation in Αβ25-35 treatment conditions. Cell killing was significantly enhanced by addition of increasing concentrations of Αβ25-35. Pretreatment of BCS attenuated in cell killing enhanced by increasing concentrations of Αβ25-35. MDA level induced by Αβ25-35 treatment was significantly increased and the level was slightly reduced by pretreatment of BCS. The present study showed that Αβ25-35 strongly increased MDA level and the level was enhanced by addition of increasing concentrations of In conclusion, it was shown that Αβ25-35 is not only potent lipid peroxide inducer, but also cause protection of neurodegeneration induced by Αβ25-35. It can be concluded that the activation of antioxidative enzymes may be related to the inhibition of lipid peroxidative reactions. We cannot fully explain to effects of BCS at present; however, the ability of BCS to reduce cell killing and MDA level induced by Αβ25-35 suggest that BCS may be a protective agent for free radical generating compounds such as Αβ25-35.
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KEYWORD
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Bombusae concretio Salicea, dementia, amyloid-β, astrocytes, lipid peroxidation
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